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gi|134133319:277-1662 Homo sapiens nuclear receptor subfamily 1, group H, member
2 (NR1H2), mRNA

1 ..

1 ATGTCCTCTC CTACCACGAG TTCCCTGGAT ACCCCCCTGC CTGGAAATGG

51 CCCCCCTCAG CCTGGCGCCC CTTCTTCTTC ACCCACTGTA AAGGAGGAGG

101 GTCCGGAGCC GTGGCCCGGG GGTCCGGACC CTGATGTCCC AGGCACTGAT

151 GAGGCCAGCT CAGCCTGCAG CACAGACTGG GTCATCCCAG ATCCCGAAGA

201 GGAACCAGAG CGCAAGCGAA AGAAGGGCCC AGCCCCGAAG ATGCTGGGCC

251 ACGAGCTTTG CCGTGTCTGT GGGGACAAGG CCTCCGGCTT CCACTACAAC

301 GTGCTCAGCT GCGAAGGCTG CAAGGGCTTC TTCCGGCGCA GTGTGGTCCG

351 TGGTGGGGCC AGGCGCTATG CCTGCCGGGG TGGCGGAACC TGCCAGATGG

401 ACGCTTTCAT GCGGCGCAAG TGCCAGCAGT GCCGGCTGCG CAAGTGCAAG

451 GAGGCAGGGA TGAGGGAGCA GTGCGTCCTT TCTGAAGAAC AGATCCGGAA

501 GAAGAAGATT CGGAAACAAC AGCAGCAGGA GTCACAGTCA CAGTCGCAGT

551 CACCTGTGGG GCCGCAGGGC AGCAGCAGCT CAGCCTCTGG GCCTGGGGCT

601 TCCCCTGGTG GATCTGAGGC AGGCAGCCAG GGCTCCGGGG AAGGCGAGGG

651 TGTCCAGCTA ACAGCGGCTC AAGAACTAAT GATCCAGCAG TTGGTGGCGG

701 CCCAACTGCA GTGCAACAAA CGCTCCTTCT CCGACCAGCC CAAAGTCACG

751 CCCTGGCCCC TGGGCGCAGA CCCCCAGTCC CGAGATGCCC GCCAGCAACG

801 CTTTGCCCAC TTCACGGAGC TGGCCATCAT CTCAGTCCAG GAGATCGTGG

851 ACTTCGCTAA GCAAGTGCCT GGTTTCCTGC AGCTGGGCCG GGAGGACCAG

901 ATCGCCCTCC TGAAGGCATC CACTATCGAG ATCATGCTGC TAGAGACAGC

951 CAGGCGCTAC AACCACGAGA CAGAGTGTAT CACCTTCTTG AAGGACTTCA

1001 CCTACAGCAA GGACGACTTC CACCGTGCAG GCCTGCAGGT GGAGTTCATC

1051 AACCCCATCT TCGAGTTCTC GCGGGCCATG CGGCGGCTGG GCCTGGACGA

1101 CGCTGAGTAC GCCCTGCTCA TCGCCATCAA CATCTTCTCG GCCGACCGGC

1151 CCAACGTGCA GGAGCCGGGC CGCGTGGAGG CGTTGCAGCA GCCCTACGTG

1201 GAGGCGCTGC TGTCCTACAC GCGCATCAAG AGGCCGCAGG ACCAGCTGCG

1251 CTTCCCGCGC ATGCTCATGA AGCTGGTGAG CCTGCGCACG CTGAGCTCTG

1301 TGCACTCGGA GCAGGTCTTC GCCTTGCGGC TCCAGGACAA GAAGCTGCCG

1351 CCTCTGCTGT CGGAGATCTG GGACGTCCAC GAGTGA

Summary
Official Symbol NR1H2

Official Full Name nuclear receptor subfamily 1, group H, member 2


Primary source HGNC:7965
See related Ensembl:ENSG00000131408; HPRD:02660; MIM:600380
Gene type protein coding
RefSeq status VALIDATED
Organism Homo sapiens
Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as NER; UNR; LXRB; LXR-b; NER-I; RIP15; NR1H2
Summary The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM]

chromosome: 19; Location: 19q13.3-q13.3




Official Symbol NR1H3

Official Full Name nuclear receptor subfamily 1, group H, member 3


Primary source HGNC:7966
See related Ensembl:ENSG00000025434; HPRD:07211; MIM:602423
Gene type protein coding
RefSeq status VALIDATED
Organism Homo sapiens
Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as LXRA; LXR-a; RLD-1; NR1H3
Summary The liver X receptors, LXRA and LXRB (NR1H2; MIM 600380), form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM]




chromosome: 11; Location: 11p11.2

課程名稱 : 生物資訊分析課程
指導老師 : 鄧致剛 老師
系所 : 生醫所生理藥理組碩一
學號 : M9801315
學生姓名 : 李姿儀