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Summary
Official Symbol NR1H2
Official Full Name nuclear receptor subfamily 1, group H, member 2
Primary source HGNC:7965
See related Ensembl:ENSG00000131408; HPRD:02660; MIM:600380
Gene type protein coding
RefSeq status VALIDATED
Organism Homo sapiens
Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as NER; UNR; LXRB; LXR-b; NER-I; RIP15; NR1H2
Summary The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM]
chromosome: 19; Location: 19q13.3-q13.3
Official Symbol NR1H3
Official Full Name nuclear receptor subfamily 1, group H, member 3
Primary source HGNC:7966
See related Ensembl:ENSG00000025434; HPRD:07211; MIM:602423
Gene type protein coding
RefSeq status VALIDATED
Organism Homo sapiens
Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as LXRA; LXR-a; RLD-1; NR1H3
Summary The liver X receptors, LXRA and LXRB (NR1H2; MIM 600380), form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM]
chromosome: 11; Location: 11p11.2
Official Symbol NR1H2
Official Full Name nuclear receptor subfamily 1, group H, member 2
Primary source HGNC:7965
See related Ensembl:ENSG00000131408; HPRD:02660; MIM:600380
Gene type protein coding
RefSeq status VALIDATED
Organism Homo sapiens
Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as NER; UNR; LXRB; LXR-b; NER-I; RIP15; NR1H2
Summary The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM]
chromosome: 19; Location: 19q13.3-q13.3
Official Symbol NR1H3
Official Full Name nuclear receptor subfamily 1, group H, member 3
Primary source HGNC:7966
See related Ensembl:ENSG00000025434; HPRD:07211; MIM:602423
Gene type protein coding
RefSeq status VALIDATED
Organism Homo sapiens
Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as LXRA; LXR-a; RLD-1; NR1H3
Summary The liver X receptors, LXRA and LXRB (NR1H2; MIM 600380), form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM]
chromosome: 11; Location: 11p11.2
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